The Science Behind Zobria®

by Dr. Richard Mann

Millions of people suffer with numbness, burning, or pain in their feet and legs with little hope for relief.  As a physician and medical researcher, I became singularly focused on understanding the mechanisms that can cause these maddening symptoms and finding a way to offer relief to my patients.  I dove into the research literature and data to understand the nutrient deficiencies that can cause these symptoms as well as the underlying health conditions that affect the way your body processes these nutrients.  Sadly, what I found was that the supplements that are commonly recommended and prescribed were just not doing the job.  That’s why I invented Zobria®. Using Zobria®, many people feel an improvement in their nerve function–improved sensation and decreased pain in the feet and legs–in as little as 30 days. 

So, why does this happen?  Why would a nutrient deficiency have anything to do with numbness, burning or pain in your feet and legs? For those of you interested in the science, especially those who didn’t major in biology, I’ll take a bit of time here to explain.


The Biology—Why Good Nerve Cells Go Bad

Nerve cells, also known as neurons, have very high rates of metabolism compared to other cell types. As a consequence, neurons are very sensitive to decreased levels of ATP production, a process that is dependent on adequate levels of vitamin B1, also known as thiamine. Decreased thiamine levels disrupt the ability of neurons to perform their primary function, the conduction action potentials. In the central nervous system—the brain and spinal cord—this deficiency often manifests itself clinically as decreased mental acuity. In the peripheral nervous system–the nerves that run from the central nervous system to the arms, legs, torso, and face–this deficiency often manifests itself as impaired sensations such as numbness, burning, tingling, and nerve pain. As such,  a thiamine deficiency should be suspected in anyone exhibiting these symptoms. 

A vitamin B1/thiamine deficiency is more common than is generally recognized. For example, diabetics have been shown to urinate out their vitamin B1 at a rate 16 or more times that of nondiabetics. As a consequence,  thiamine deficiency is thought to be highly prevalent among the estimated 35 million diabetics in the US. Other groups of people at increased risk of vitamin B1 deficiency include the elderly, people with a history of alcohol abuse, and people taking certain medications. It is therefore not surprising that numbness, tingling, burning, or nerve pain are common in these groups.


Why Vitamin B1 Alone Doesn’t Work

But it’s not as simple as just taking additional vitamin B1. I noticed that patients in my practice who supplemented with over-the-counter B1 weren’t getting the relief they had hoped for. To understand why, you need to know more about thiamine/B1. It is a water-soluble vitamin. Its absorption from the intestines is dependent upon thiamine transporter molecules. This energy-dependent process transports vitamin B1 from the intestinal lumen into the cells that line the intestines. From there the vitamin enters the bloodstream and is distributed throughout the body. Unfortunately, this process can be impaired by many factors including damage to the transporter molecules and substrate competition from medications. It has been noted that less than 5% of water-soluble vitamin B1 is actually absorbed from the intestine.  

Benfotiamine, one of the key ingredients in Zobria®, is a fat-soluble form of vitamin B1. It is absorbed much more successfully than dietary vitamin B1 or standard vitamin B1 pills. The lipid composition of the intestinal lining allows benfotiamine to be absorbed by passive diffusion.  This process is independent of thiamine transporters and is highly efficient. As a result, benfotiamine has been shown to elevate vitamin B1 levels more successfully than any other commercially available product.   It is extremely safe and very well studied.  It is an ideal agent for reversing nerve dysfunction due to vitamin B1 deficiency and is included in my formula in just the right dosage.

The Most Effective Vitamin B12

In addition to benfotiamine, Zobria® contains just the right amount of methylcobalamin–the most desirable form of vitamin B12. Zobria® is formulated with methylcobalamin, the preferred form of vitamin B12 owing to superior bioavailability and safety. It remains in the body longer and at higher levels than more commonly used forms of vitamin B12, providing your body with access to vitamin B12 for a longer duration.

Vitamin B12 is an essential dietary nutrient, and a deficiency can lead to a number of serious conditions including peripheral neuropathy. Vitamin B12 deficiency is common in the United States – reliable estimates say that 50% of people with a B12 deficiency may suffer with numbness, burning or pain in the feet and legs.  There are many causes of B12 deficiency, including dietary choices, the use of antacids and other OTC and prescription medications, as well as a variety of medical conditions. 


Zobria® Works!

Thousands of top physicians around the world have been using my Zobria® formula, benefitting many thousands of their patients suffering with numbness, burning or pain in their feet and legs.  I’m grateful for the opportunity to help so many, and hope that you’ll try Zobria® and see what it can do for you!